Two Committees will provide oversight and policymaking for the PR-AABRE program.

The PR-AABRE Steering Committee with be the program's policymaking body. It is constituted by representative of all institutions participating in the Alliance, by representatives of the 4 Cores constituting the PR-AABRE program, as well as by the Vice President for Research of the University of Puerto Rico System.

The PR-AABRE External Advisory Committee consists of distinuguished scientists who are experts in all the areas of investigation of the thrust areas of PR-AABRE, including bioinformatics.